Allergy Associated With N-glycans on Glycoprotein Allergens
Protein as the allergens could lead to allergy.In addition,a widespread class of allergens were known as glycans of N-glycoprotein.N-glycoprotein contained oligosaccharide linked by covalent bonds with protein.Recently,studies implicated that allergy was associated with glycans of heterologous N-glycoprotein found in food,inhalants,insect toxins,etc.The N-glycan structure of N-glycoprotein allergen has exerted an influence on the binding between allergens and IgE,while the recognition and presentation of allergens by antigen-presenting cells(APCs)were also affected.Some researches showed that N-glycan structure of allergen was remodeled by N-glycosidase,such as cFase Ⅰ,gpcXylase,as binding of allergen and IgE partly decreased.Thus,allergic problems caused by N-glycoproteins could potentially be solved by modifying or altering the structure of N-glycoprotein allergens,addressing the root of the issue.Mechanism of N-glycans associated allergy could also be elaborated through glycosylation enzymes,alterations of host glycosylation.This article hopes to provide a separate insight for glycoimmunology perspective,and an alternative strategy for clinical prevention or therapy of allergic diseases.
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