间断theta脉冲磁刺激对空间工作记忆相关神经振荡及其同步性的影响

扫码查看

原文链接

万方数据
维普

中文摘要：目的间断theta脉冲磁刺激(iTBS)已被证实可以通过夹带大脑不同频段神经振荡调控工作记忆功能，但其对神经振荡及其同步性的调节尚不清晰。本研究旨在探讨iTBS对大鼠局部脑区及跨脑区神经振荡及其同步性的影响，探究iTBS调控工作记忆的作用机制。方法24只大鼠根据年龄及是否接受iTBS分为4组，应用时频分布、相位同步性以及相位-幅值耦合分析方法，对比分析各组大鼠在进行空间工作记忆(SWM)行为学任务的过程中前额叶和海马脑区theta及gamma频段局部场电位信号神经振荡的变化规律。结果随着年龄增长，老年大鼠学会SWM任务规则所用时间明显增加(P=0。005 6);iTBS可以缩短成年大鼠(P=0。001 1)和老年大鼠(P=0。0090)学会SWM任务规则所用时间。相比成年大鼠，老年大鼠前额叶和海马脑区theta和gamma频段神经振荡的时频能量(theta:P＜0。000 1;gamma:P＜0。000 1)、跨脑区相位-幅值耦合作用(PFC-HPC:P=0。000 2;HPC-PFC:P=0。027 7)均出现一定程度的下降;iTBS可以提高成年大鼠(theta:P＜0。000 1;gamma:P＜0。000 1)和老年大鼠(theta:P=0。014 4;gamma:P=0。000 6)神经振荡的时频能量以及老年大鼠跨脑区相位-幅值耦合作用(PFC-HPC:P=0。018 0;HPC-PFC:P=0。022 1)。此外，两脑区各频段信号的时频能量及相位-幅值耦合与大鼠行为学正确率均具有正相关关系。结论iTBS可以增强老年大鼠的SWM能力以及认知功能，这与老年大鼠SWM任务期间跨脑区theta频段和gamma频段神经振荡的时频能量以及跨脑区相位幅值耦合增强有关。对于成年大鼠，iTBS通过提升成年大鼠SWM任务期间两脑区theta频段和gamma频段神经振荡的时频能量增强其SWM能力与认知功能。

外文标题：Effect of Intermittent Theta Burst Stimulation on Spatial Working Memory-related Neural Oscillations and Their Synchronicity

外文摘要：Objective Spatial working memory(SWM)is an important function in cognitive behavior,and working memory impairment can seriously affect the patient's life and cause great stress to the patient.Intermittent theta burst stimulation(iTBS)has been shown to regulate working memory function by entrainment of neural oscillations in different frequencies of the brain,but its regulation of working memory-related neural oscillations and their synchronization is not clear.The purpose of this study was to study the effect of iTBS on neural oscillation and synchronization in local and transbrain regions of rats,and to explore the mechanism of iTBS in regulating working memory.Methods Twenty-four rats were randomly divided into four groups according to their age and whether they received iTBS stimulation(AS:adult stimulation group,AC:adult control group,ES:elderly stimulation group,EC:elderly control group).Using the methods of time-frequency distribution,phase synchronization and phase-amplitude coupling analysis,the changes of local field potential signal neural oscillations in the prefrontal and hippocampal brain regions of theta and gamma bands in the process of spatial working memory behavioral tasks in each group of rats were compared and analyzed,and the relationship between the changes of neural oscillations in the two brain regions and the changes in spatial working memory ability of rats was judged based on the Pearson correlation coefficient.Results With the increase of age,the time taken by the elderly rats to learn the spatial working memory task rules increased significantly(P=0.005 6),and the time taken by iTBS stimulation to learn the SWM task rules in adult rats(P=0.001 1)and elderly rats(P=0.009 0)was shortened.At the same time,compared with adult rats,the time-frequency energy of theta and gamma band neural oscillations in the prefrontal and hippocampal brain regions of elderly rats(theta:P＜0.000 1;gamma:P＜0.000 1)and phase-amplitude coupling across brain regions(PFC-HPC:P=0.000 2;HPC-PFC:P=0.027 7)decreased to a certain extent,and iTBS stimulation could increase the time-frequency energy of neural oscillations of adult rats(theta:P＜0.000 1;gamma:P＜0.000 1)and elderly rats(theta:P=0.014 4;gamma:P=0.000 6)and the phase-amplitude coupling effect across brain regions in elderly rats(PFC-HPC:P=0.018 0;HPC-PFC:P=0.022 1).In addition,the time-frequency energy and phase-amplitude coupling of signals in each frequency band of the two brain regions were positively correlated with the behavioral accuracy of rats,while the phase synchronization of theta band and gamma band neural oscillations in the two brain regions during working memory was not correlated with the behavioral accuracy.Conclusion iTBS can enhance SWM ability and cognitive function in elderly rats,and this improvement is associated with increased coupling of time-frequency energy and cross-brain phase amplitude of neural oscillations across theta and gamma bands during SWM tasks.Similarly,in adult rats,iTBS enhances SWM ability and cognitive function by increasing the time-frequency energy of theta and gamma band neural oscillations in both brain regions during SWM tasks.Furthermore,in addition to the main findings,this study provides evidence supporting the state-dependent effects of iTBS stimulation to some extent.

外文关键词：

intermittent theta burst stimulationspatial working memorynerve oscillationsphase synchronicityphase-amplitude coupling

作者：

郭苗苗、张彪、张天恒、王田、翟昊迪、徐桂芝

展开 >

作者单位：

河北工业大学生命科学与健康工程学院,天津 300130

河北工业大学,省部共建电工装备可靠性与智能化国家重点实验室,天津 300130

河北工业大学,天津市生物电工与智能健康重点实验室,天津 300130

河北工业大学,河北省生物电磁学与神经工程重点实验室,天津 300130

石家庄学院机电学院,石家庄 050035

展开 >

关键词：

间断theta脉冲磁刺激空间工作记忆神经振荡相位同步性相位-幅值耦合

基金：

国家自然科学基金国家重点研发计划河北省自然科学基金河北省自然科学基金河北省科技计划河北省科技计划河北省科技计划天津市自然科学基金天津市自然科学基金河北工业大学电气设备可靠性与智能化国家重点实验室

项目编号：

523201050082022YFC2402203E2021202222F202420208518963001D215676146H225676163GH20JCQNJC0071021JCXJC00090EERI_OY2021009

出版年：

2024

DOI：

10.16476/j.pibb.2023.0466

生物化学与生物物理进展

中国科学院生物物理研究所,中国生物物理学会

生物化学与生物物理进展

CSTPCD北大核心

影响因子：0.476

ISSN：1000-3282

年,卷(期)：2024.51(9)