Codon preference and cluster analysis of Norovirus GⅡ.4
[Objective]Analyzed the preference changes in the codon of Norovirus GⅡ.4 genotype and explored its clustering situation.[Method]Downloaded all complete strains of G Ⅱ.4 from NCBI,analyzed the codon preference of Norovirus G Ⅱ.4 using CodonW,EMBOSS and SigmaPlot14.0,and performed cluster analysis on G Ⅱ.4 using SPSS software.[Result]The ENC values of the three coding boxes of Norovirus G Ⅱ.4 were all greater than 50;Most codons with RSCU>1 end with U/C;ENC-Plot showed that the vast majority of the three coding boxes of G Ⅱ.4 type were located below the standard curve;In PR2 a-nalysis,the distribution of the four quadrants of the three coding boxes of G Ⅱ.4 type is uneven;The clustering analysis of GⅡ.4 type by year showed that there was a certain degree of clustering between different years.[Conclusion]The preference of the three encoding boxes in GⅡ.4 was weak,and the codon usage was mainly U/C terminated.Its usage bias was mainly in-fluenced by natural selection.In recent years,there had been new clustering situations that need to be taken seriously.
NETL
NSTL
万方数据
