SLC2A5基因及其在胰腺癌细胞中作用
SLC2A5 gene and its progression in pancreatic cancer cells
张兰 1刘森2
作者信息
- 1. 湖北工业大学工业发酵省部共建协同创新中心,湖北武汉 430068;湖北微生元生物科技有限公司,湖北鄂州 436006
- 2. 湖北工业大学工业发酵省部共建协同创新中心,湖北武汉 430068;湖北工业大学发酵工程教育部重点实验室,湖北武汉 430068
- 折叠
摘要
胰腺癌是世界上恶劣的肿瘤之一,其存在早期诊断难于被发现,缺乏有效治疗手段以及预后效果较差等问题.近几年研究显示SLC2A5基因的上调、缺失与胰腺癌的发展、迁移相关.SLC2A5基因编码的果糖特异转运体Glut5参与细胞中果糖代谢的过程.果糖是日常生活中常见的糖源,过量摄入导致癌症的发生和迁移.该文总结了 SLC2A5基因的来源、生物学功能以及其在胰腺癌中的代谢情况和作用机制,分析认为SLC2A5基因不仅影响胰腺癌生长迁移,而且可能成为胰腺癌治疗的潜在靶向研究.
Abstract
Pancreatic cancer is one of the worst tumors in the world.It has questions such as difficulty in early diagnosis,lack of clinically effective treatment methods,and poor prognosis.According to the relevant literature in recent years,the up-regula-tion and deficiency of SLC2A5 gene are related to the development and migration of pancreatic cancer.The fructose-specific transporter Glut5 encoded by the SLC2A5 gene is involved in the process of fructose metabolism in cells.Fructose is a common sugar source in daily life,and excessive intake affects the occurrence and migration of cancer.This paper summarizes the source and biological function of SLC2A5 gene and the metabolism and mechanism of SLC2A5 gene in pancreatic cancer.It is consid-ered that SLC2A5 gene not only affects the growth and migration of pancreatic cancer,but also may become a potential target for the treatment of pancreatic cancer.
关键词
胰腺癌/SLC2A5基因/迁移/果糖/生物学功能/代谢/机制/靶点Key words
pancreatic cancer/SLC2A5 gene/migration/fructose/biological functions/metabolism/mechanism/target引用本文复制引用
基金项目
国家自然科学基金面上项目(31971150)
湖北省杰出青年基金(2019CFA069)
湖北省工业发酵省部共建协同创新中心开放基金()
出版年
2024
NETL
NSTL
万方数据