Brain-gut connection:probiotics'regulatory mechanisms in autism spectrum disorder
Autism spectrum disorder(ASD)was considered a childhood neurodevelopmental disorder.In recent years,there has been a significant increase in the prevalence of ASD,with its causation involving various factors such as genetics,environ-ment,and neural development.Due to the complex etiology and substantial individual differences,there was no effective cure for the condition.However,in recent studies,it has been suggested that probiotics might ameliorate symptoms of ASD,depression,anxiety,and other neurological disorders by regulating gut microbiota and their metabolites,thus restoring gut microbiome bal-ance and impacting the central nervous system through the gut-brain axis.This review aims to summarize potential regulatory pathways of probiotics in improving ASD symptoms,building on the foundation of the bidirectional regulation mechanism of the"brain-gut axis,"with the intention of providing some guiding principles for ASD treatment strategies.
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