Progress on regulation of nitric oxide synthesis by valproic acid
Valproic acid(VPA)is a kind of short-chain fatty acid that can pass through the blood-brain barrier,which has the risk of teratogen,neurodevelopmental disorders and even death.It also has the functions of protecting cardiovascular and ce-rebrovascular,anti-epilepsy,reducing kidney damage,inhibiting bacteria and promoting nerve cell differentiation.These pro-tective effects are closely related to the synthesis of nitric oxide(NO).NO is a small molecule of free radicals necessary to maintain normal physiological functions in the human body.The imbalance of NO will change cell function and cause pathologi-cal diseases in the human body.VPA enhances teratogenicity by inhibiting NO synthesis,promoting NO synthesis to enhance vascular protection,antiepileptic,bacteriostatic,inducing cell differentiation,and alleviating kidney injury caused by NO defi-ciency.This review introduces for the first time the above-mentioned effects of VPA on the body by regulating NO synthesis,and summarizes the pathway of VPA regulating NO and its corresponding effects.
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