Research progress in nuclear m6A reader proteins and alternative splicing in diseases
N6-methyladenosine is a dynamic and reversible epigenetic modification,which is the most common internal post-transcriptional modification.Methylation enzymes catalyze m6A modification,while demethylation enzymes remove the modifi-cation.The modified RNA is specifically recognized by reader proteins that depend on m6A modification.The m6A modification regulates the pattern of alternative splicing by recruiting RNA-binding proteins that regulate alternative splicing or by directly influencing the interaction between RNA-binding proteins and their target RNA.The m6A modification expands the scope of disease treatment strategies,while alternative splicing provides new insights into the mechanisms of m6A reader proteins in dis-ease occurrence and progression.This article introduces the interaction between m6A reader proteins and alternative splicing,comprehensively summarizes the regulatory mechanisms of all nuclear m6A reader proteins on messenger RNA recognition and alternative splicing,focuses on the biological functions and mechanisms of m6 A reader proteins in various diseases such as cancer,influenza virus,and leukemia,and explores the potential strategies of m6A-dependent alternative splicing in treatment.
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