Research advances in m6A-mediated oxidative stress and DNA damage in aging
m6A is a dynamic and reversible epitranscriptomic regulation that plays a crucial role in various biological proces-ses.In recent years,the involvement of m6A modification in the regulation mechanisms of aging and aging-related processes has attracted increasing attention,offering a possibility to understand the molecular mechanisms of aging and develop new thera-peutic strategies.This article focuses on the potential mechanisms by which m6A modification mediates the regulation of oxida-tive stress and DNA damage-induced aging,and summarizes the potential therapeutic directions of m6A in aging and related processes.Finally,the limitations and technical challenges in understanding the epitranscriptomic regulation of m6A in aging processes are discussed,emphasizing the potential directions for future research.
m6 Aagingoxidative stressDNA damagemethyltransferasedemethylasereader protein
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