[Objective]The effects of fengycin on the metabolism of mouse spleen tissues were investigated by metabolomic a-nalysis of the spleens of fengycin-fed mice.[Method]Sixteen healthy male SPF-grade C57 mice were divided into the fengy-cin-treated group and the control group.After eight weeks of ad libitum feeding,the spleens of the mice were processed and detected by high performance liquid chromatography-mass spectrometry to identify the characteristic metabolites and metabolic pathways with differences.[Result]After metabolomics analysis,15 different metabolites were identified in the treated group compared with the control group,which significantly affected six metabolic pathways,including histidine metabolism,sphingolip-id metabolism,glycerophospholipid metabolism,D-glutamine and D-glutamate metabolism,arginine metabolism,and alanine,aspartic acid and glutamate metabolism.[Conclusion]Fengycin interfered with the homeostasis of multiple metabolic pathways in mice and reduced their anti-inflammatory and antioxidant capacity,causing damage to their organic health.
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