Chitosan,a naturally occurring cationic polymer derived from partial deacetylation of chitin,holds great promise as a non-viral gene delivery vector in the field of biomedicine.Recent studies in gene therapy have demonstrated that chitosan and its derivatives can effectively enhance the targeting and delivery efficiency of genes both in vitro and in vivo,showing excellent prospects in various gene therapy areas such as anti-tumor therapy,gene editing,therapeutic diagnostics,and wound healing.This article examines recent progress in the use of chitosan and its derivatives for gene delivery,elucidating their mechanisms of delivery.Additionally,it discusses the key factors influencing their efficient gene delivery and explores the future prospects of chitosan-based gene carriers,aiming to provide insights for the research and application of chitosan and its derivatives in gene therapy.
gene therapydelivery systemnon-viral gene carrier materialschitosanchemical modificationanti-tumornucleic acidmechanism of action
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