Because of the characters of effective,safe and easy to be produced on a large scale,mRNA drugs have showed great po-tential on preventing viral infections.mRNA represents an emerging field of precision medicine,several mRNA drugs targeted thera-pies for infectious diseases and cancer have shown beneficial results both in vivo and in vitro.mRNA is stable,immunogenic,and not limited by the receptor's major histocompatibility complex(MHC)type.In theory,mRNA can achieve in vivo expression of dif-ferent target proteins,which makes the development of mRNA drugs more flexible and can be used to prevent and treat many refrac-tory or hereditary diseases.This paper introduced the primary structure and higher structure of mRNA,and summarized the prog-ress of mRNA drugs in clinical application,which was expected to help understand the drug function of mRNA,and the clinical ap-plication,and provide the direction for the development of mRNA drugs.
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