诺如病毒(norovirus,NoV)是引发急性胃肠炎疾病的主要病原体之一.NoV易发生突变产生多种毒株,对人类健康造成严重威胁.由于缺乏成功的动物模型,抗NoV药物和疫苗的后续评价受到了限制,目前尚没有上市的疫苗用于NoV的预防.对NoV疫苗的研究进展进行了综述,重点阐述了病毒样颗粒(virus like particles,VLP)疫苗、病毒载体疫苗和基于P颗粒疫苗的研究现状和发展前景,以期为NoV疫苗的研发提供新思路.
Overview of Norovirus Vaccine Research
Norovirus(NoV)is one of the main pathogens causing acute gastroenteritis.NoV is prone to mutating and producing multi-ple strains that pose a significant threat to human health.Subsequent evaluation of anti-NoV drugs and vaccines is limited by the lack of successful animal models,and no vaccines are currently on the market for NoV prevention.In this paper,the research progress of NoV vaccine was reviewed,focusing on the research status and development prospects of virus-like particle(VLP)vaccine,viral vector vaccine and P-particle based vaccine,in order to provide new ideas for NoV vaccine research and development.
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