Tumor microenvironment has been recognized as an important part of tumor development.Extracellular matrix proteins present in tumor microenvironment play key roles in biological regulation of tumor cells such as unlimited proliferation,metasta-sis,immune escape and drug resistance to chemotherapy.Fully understanding the molecular interaction mechanism in the tumor microenvironment and giving effective intervention measures in time would help to explore new therapeutic targets and inhibit tu-mor progression.According to recent research,periostin(POSTN),one of extracellular matrix proteins,interacts with numerous components of the tumor microenvironment and is also involved in the biological processes of many malignancies.In order to de-termine the possibility of POSTN as a therapeutic target,this review presented the recent findings about the involvement of POSTN in the incidence and development of malignancies from the viewpoint of the tumor microenvironment.
维普
万方数据