首页|线粒体生物合成在糖尿病心肌病中的研究进展

线粒体生物合成在糖尿病心肌病中的研究进展

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糖尿病心肌病(diabetic cardiomyopathy,DCM)是糖尿病(diabetesmellitus,DM)最严重和最常见的并发症之一,其发病机制尚未明确.越来越多的研究表明,线粒体稳态与DCM病程的发展密切相关.线粒体生物合成作为线粒体稳态的重要组成部分,参与DCM的发生发展过程.通过调节线粒体生物合成相关的分子机制以改善线粒体功能,有望做为防治DCM的新靶点.根据近年来国内外文献,总结了线粒体生物合成在DCM中的作用机制和研究进展,以期为DCM的预防和治疗提供参考.
Research Progress of Mitochondrial Biosynthesis in Diabetes Cardiomyopathy
Diabetic cardiomyopathy(DCM)is one of the most serious and common complications of diabetesmellitus(DM),and its pathogenesis is not well understood.A growing body of studies has shown that mitochondrial homeostasis is closely related to the development of DCM.Mitochondrial biosynthesis,as an important part of mitochondrial homeostasis,is involved in the oc-currence and development of DCM.Improving mitochondrial function by regulating molecular mechanisms related to mitochondri-al biosynthesis may be a new target for the prevention and treatment of DCM.Based on the literature at home and abrod in recent years,the mechanism and research progress of mitochondrial biosynthesis in DCM were summarized in order to provide a refer-ence for the prevention and treatment of DCM.

diabetic cardiomyopathymitochondrial biosynthesishypoglycemicsmitochondrial homeostasis

王钰淇、王心雨、王颖凡、孟远翠、严喜章、常盼

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西安医学院第二临床医学院麻醉系,西安 710038

西安医学院第二附属医院新生儿科,西安 710038

西安医学院第二附属医院心内科,西安 710038

糖尿病心肌病 线粒体生物合成 降糖药 线粒体稳态

国家自然科学基金陕西省科技厅自然基础重点项目西安医学院大学生创新创业训练计划陕西省教育厅产业化项目

823004072023-JC-ZD-55S20231184006323JC059

2024

生物技术进展
中国农业科学院茶叶研究所 中国农业科学院生物科技研究所

生物技术进展

CSTPCD
影响因子:0.554
ISSN:2095-2341
年,卷(期):2024.14(2)
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