Aging is an irresistible natural change in the organisms over time,manifested by changes of the morphological struc-tures,decline of physiological functions,and occurrence of many geriatric diseases.Spermidine,a natural polyamine,shows great potential in alleviating the aging process.Recent studies showed that spermidine could clean senescent cells,repair dam-aged tissues,reduce the occurrence of aging-related diseases by activating autophagy,clean damaged mitochondria,interfere the lipid metabolism and regulate cell cycles.The major synthesis processes in vivo and in vitro,molecular mechanisms to allevi-ate aging,and therapeutic roles in aging-related diseases of spermidine were systematically described in this review,in order to provide reference for the prognosis and clinical treatment of age-related diseases.
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