Research Progress on Glycolipid Metabolism Reprogramming of Macrophage in Non-alcoholic Fatty Liver Disease
Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in China,involving various pathophysiological processes such as steatosis,inflammation,and fibrosis.The liver contains a large number of macrophages.More and more evidence suggests that the glycolipid metabolism characteristics of macrophages have changed significantly during the progress of non-alcoholic fatty liver disease,and the regulation of metabolism can regulate the immune function of macro-phages,which in turn affects the local inflammatory environment of the liver and the metabolism of hepatocytes.This article re-viewed the changes in glycolipid metabolism of macrophages during the progress of NAFLD and the key molecules involved in the above processes,in order to find new targets for the treatment of NAFLD.
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