Research Progress of Fas-mediated Non-apoptotic Signaling in Tumor Cells
FAS is a membrane protein receptor expressed in a variety of cells.After binding to its ligand FASL,the downstream signal in cells is activated,which can lead to a kind of programmed cell death-apoptosis.Fas-induced apoptosis is an important factor in inhibiting or killing tumor cells in many cell types.In recent years,it has been found that FAS can activate biological functions opposite to apoptosis in certain cellular microenvironment conditions or tumor types,including cell proliferation and migration.However,the role and mechanism of Fas-mediated non-apoptotic pathway are not completely clear,and the relationship between Fas-mediated non-apoptotic pathway and classical apoptotic pathway is also lack of research.Further investigation is needed to determine under what conditions and in which cells or tumor types Fas-mediated non-apoptotic pathway plays a role.This review described the proliferative effect of FAS-mediated non-apoptotic signaling pathway in tumor cells,with a focus on summarizing several key fac-tors in its non-apoptotic pathway,aiming at providing idea for the new clinical treatment methods and new drug research in tumors.
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