To explore the function of Limosilactobacillus reuteri HCS02-001 in relieving hyperuricemia and gout,it was inoculat-ed in the culture medium containing inosine and guanosine for a certain period of time,and the content changes of inosine and guanosine in the reaction solution were determined to confirm its ability to decompose purine nucleosides in vitro.Then 63 pa-tients with hyperuricemia were randomly divided into control group and intervention group.Both groups were treated with alka-lized urine on the basis of basic treatment,and the intervention group was treated with Limosilactobacillus reuteri freeze-dried powder for 30 days.The results of functional test in vitro showed that after 1 hour of culture with Limosilactobacillus reuteri HCS02-001,the degradation rate of inosine and guanosine were 62.07%and 73.53%,respectively.After 2 hours of culture,the degradation rate of inosine and guanosine were 61.29%and 67.65%,respectively.The population experiment showed that Limosi-lactobacillus reuteri HCS02-001 could significantly increased the total clinical effective rate,reduced the content of serum uric acid,inflammatory factor serum C-reactive protein(CRP),total cholesterol(TC),triglycerides(TG),and low-density lipopro-tein cholesterol(LDL-C),increased high-density lipoprotein cholesterol(HDL-C)levels.At the same time,it is safe to improve the phenomenon of joint bone erosion in patients.In conclusion,Limosilactobacillus reuteri HCS02-001 can effectively relieve hy-peruricemia and gout without side effects.
维普
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