Comparative Analysis of Platelet Transcriptome and Proteome Changes in SARS-CoV2 Omicron Infection
As an important blood component,platelets play a key role in the maintenance of homeostasis and the stress of diseas-es infection.The absence of nuclei and the diversity of transcripts and protein sources lead to a generally low transcriptomic and pro-teomic correlation of platelets.Previous research have analyzed the dynamic expression patterns of platelet proteome at different stages of severe acute respiratory syndrome coronavirus 2(SARS-CoV2)Omicron infection,but the specific sources have not been thoroughly analyzed.In order to further understand the mechanism of platelet response in Omicron infection,we compared the platelet proteome with the transcript to explore the sources of different protein molecules.The results showed that the changes of platelet transcriptome were more drastic than those of proteome,and the changes of the two were different.The genes/proteins co-upregulated by platelet transcriptome and proteome after infection mainly enriched innate immunity and antiviral immune response,suggesting that related proteins may be derived from RNA translation in platelets.The upregulation features of platelet proteome in-cluded acute inflammatory response and phagocytosis recognition,suggesting that this part of the protein may be obtained by di-rect plasma intake or interaction with other cells.In addition,platelet transcriptome also independently up-regulated RNA metabo-lism and RNA splicing regulation and other related genes.This study provides important data support for exploring the diversity of platelet RNA and protein sources under Omicron infection.
万方数据
维普
