病毒样颗粒疫苗研究进展
Research Progress of Virus-like Particles Vaccine
赵尉吏 1吕娜 1李会强 1何亚辉 1李露露 1梁明丽 1李岩异1
作者信息
- 1. 华北制药金坦生物技术股份有限公司,石家庄 050035
- 折叠
摘要
病毒样颗粒(virus-like particles,VLPs)是含有某种病毒一个或多个结构蛋白的空心颗粒形态,结构上类似完整病毒,具有与完整病毒相似的免疫原性并通过激活抗原提呈细胞诱导免疫应答,由于不含有完整的病毒基因组,因此适合用于开发更安全、成本更低的候选疫苗.系统阐述了VLPs的分类、表征、优势及表达系统,回顾了VLPs疫苗的发展历程,并汇总了已上市的疫苗品种.同时,介绍了部分在研的预防性或治疗性VLPs疫苗,并探讨了新的开发策略,进一步拓宽了VLPs疫苗的研发领域,为未来的研究与应用提供了更广阔的前景.
Abstract
Virus-like particles(VLPs)are hollow particles containing one or more structural proteins of a certain virus.Structur-ally similar to intact viruses,they possess immunogenicity similar to that of intact viruses and could induce immune responses by activating antigen-presenting cells.Due to the absence of viral genomes,VLPs can be developed into safer and more cost-effec-tive vaccine candidates.This article systematically elaborated on the classification,characterization,advantages,and expression systems of VLPs,reviewed the development history of VLP vaccines,and summarized the varieties of vaccines that have been ap-proved for market use.At the same time,it introduced some preventive or therapeutic VLP vaccines that were currently under re-search and development,and explored new development strategies,further broadening the field of VLP vaccine research and de-velopment,and providing broader prospects for future research and application.
关键词
病毒样颗粒/VLPs疫苗/表征工具/表达系统Key words
virus-like particles/VLP vaccines/characterization tools/expression system引用本文复制引用
出版年
2024
NETL
NSTL
万方数据