Obstructive Sleep Apnea and Cognitive Impairment:A Review of Epigenetic Advances
Obstructive sleep apnea(OSA)is a chronic,complex,and heterogeneous respiratory system disorder characterized by recurrent collapse of the upper airway during nighttime sleep.This disruption leads to fragmented sleep and clinical manifesta-tions such as cognitive behavioral deficits.A typical pathophysiological characteristic of OSA is chronic intermittent hypoxia(CIH),which results in varying degrees of central nervous systempathological damage and functional impairments.Epigenetic mechanisms encompass DNA methylation,histone post-translational modifications,and non-coding RNAs,which regulate pro-cesses such as stress responses,cellular hypoxia,inflammation and metabolic abnormalities.These processes are related to the pathogenesis of OSA and its underlying driving force(CIH).Therefore,a review of epigenetic research on how OSA impacts cog-nitive function and progress on OSA diagnose and therapy holded promise for future in-depth exploration of OSA's pathogenic mechanisms and the discovery of new drug targets to broaden treatment strategies.
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