Interleukin-22(IL-22)belongs to the IL-10 family and is mainly produced by T helper cells Th1,Th17,Th22,innate lymphoid cells(ILCs),CD4+T and CD8+T cells and other lymphocytes.They are cellular effectors with specific effects.With the progress of research,the correlation of IL-22 with a variety of metabolic diseases and cardiovascular diseases has been gradually revealed,and IL-22 signaling may have a dual role in them.This article reviewed the source,function,regulation of IL-22 and the role of IL-22 signaling in cardiovascular diseases,in order to provide a plan for the clinical treatment of cardiovascular diseas-es in the future.
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