Research Progress on the Imbalance of Mitochondrial Quality Control Leading to Renal Interstitial Fibrosis in Diabetic Kidney Disease
Renal interstitial fibrosis is an important pathological feature of diabetic kidney disease(diabetic kidney disease,DKD),and also an important factor to promote its development into end-stage renal disease,which seriously threatens the life safety of patients with diabetic kidney disease.At present,great progress has been made in the research of diabetic kidney mito-chondrial disease,but the specific mechanism of mitochondrial quality control in its occurrence and development is still unclear.The maintenance of eukaryotic cell function relies on mitochondria,and the maintenance of mitochondrial homeostasis depends on mitochondrial quality control,including mechanisms such as mitochondrial biogenesis,mitochondrial dynamics,mitochondrial protein homeostasis,and mitochondrial autophagy.The absence of these mechanisms may lead to mitochondrial structural dam-age and dysfunction,resulting in cell death and tissue damage.More and more evidence suggested that the imbalance of mito-chondrial quality control plays a crucial role in the occurrence and progression of renal interstitial fibrosis.This article reviewed the research progress of mitochondrial quality control in renal interstitial fibrosis of diabetic kidney disease,with a view providing new ideas for the treatment of diabetic kidney disease,so as to improve the survival rate and the life quality of patients with diabetic kidney disease.
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