海洋真菌来源的聚酮类化合物研究进展
Research Progress on Polyketides from Marine Fungi
潘少婷 1王博轩 1陈佳鑫 1蔡佳君 1林彦伸 1唐灵芝 1洪璇1
作者信息
- 1. 厦门医学院,厦门市海洋药用天然产物资源重点实验室,福建 厦门 361023
- 折叠
摘要
聚酮类化合物作为一类重要的次级代谢产物,在海洋生物中广泛分布,展现出包括抗肿瘤、抗菌、抗病毒、抗氧化及抑制酶活性在内的多种生物活性.近年来,随着对海洋资源探索的深入,源自海洋真菌的新型聚酮类化合物不断涌现,成为新药研发的重要宝库.从研究概况、生物合成途径、发酵与分离以及生物活性评估五个方面综述了海洋真菌来源的聚酮类化合物的研究进展,以期为海洋聚酮类化合物的开发与应用研究提供参考.
Abstract
As an important class of secondary metabolites,polyketides are widely found in marine organisms and rich in biologi-cal activities such as antitumor,antibacterial,antiviral,antioxidant,and enzyme inhibition.In recent years,with the exploita-tion of marine resources,many novel polyketides of marine fungal origin have been discovered,which are considered to be an im-portant source of new drugs.In this paper,the research progress of marine fungal-derived polyketides was reviewed from five as-pects:research overview,biosynthetic pathway,fermentation and isolation,and biological activity,which was expected to pro-vide reference for the study of development and application on polyketides from marine fungi.
关键词
海洋真菌/聚酮类化合物/生物合成途径/生物活性Key words
marine fungi/polyketides/biosynthetic pathway/biological activity引用本文复制引用
出版年
2024
NETL
NSTL
万方数据