首页|Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

Microarrow sensor array with enhanced skin adhesion for transdermal continuous monitoring of glucose and reactive oxygen species

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Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in vivo.Continuous glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammation may affect glucose detection.Microneedle technology is less invasive,yet microneedle adhesion with skin tissue is limited.In this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H2O2(representative of ROS)in interstitial fluid in vivo.The microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle array.Due to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into skin.The MASA was demonstrated to provide continuous in vivo monitoring of glucose and H2O2 concentrations,with the detection of H2O2 providing a valuable reference for assessing the inflammation state.Finally,the MASA was integrated into a monitoring system using custom circuitry.This work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

Microarrow sensor arrayGlucose sensingReactive oxygen species sensingIntegrated systemContinuous monitoring

Xinshuo Huang、Baoming Liang、Shantao Zheng、Feifei Wu、Mengyi He、Shuang Huang、Jingbo Yang、Qiangqiang Ouyang、Fanmao Liu、Jing Liu、Hui-jiuan Chen、Xi Xie

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State Key Laboratory of Optoelectronic Materials and Technologies,School of Electronics and Information Technology,Guangdong Province Key Laboratory of Display Material and Technology,Sun Yat-Sen University,Guangzhou 510006,China

Pazhou Lab,Guangzhou 510330,China

School of Biomedical Engineering,Sun Yat-Sen University,Shenzhen 518107,China

The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510006,China

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National Key R&D Program of ChinaNational Key R&D Program of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaGuangdong Basic and Applied Basic Research FoundationScience and Technology Program of Guangzhou,ChinaFundamental Research Funds for the Central Universities,Sun Yat-Sen UniversityPazhou Lab,GuangzhouOpening Project of Key Laboratory of Microelectronic Devices & Integrated Technology,Institute of Microelectronics,Chinese ATianjin Key Laboratory of Imaging and Sensing Microelectronic TechnologyNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaChina Postdoctoral Science FoundationChina Postdoctoral Science Foundation

2021YFF12007002021YFA09111003217139932171456T22250102021A151501226120210300007622dfx02PZL2021KF00033217133531900954621053802021M6936862022M713645

2024

10.1007/s42242-023-00246-2

生物设计与制造(英文)

生物设计与制造(英文)

ISSN：2096-5524
年,卷(期)：2024.7(1)
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