Innovation leading development:a glimpse into three-dimensional bioprinting in Israel

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外文摘要：Three-dimensional(3D)printing has attracted increasing research interest as an emerging manufacturing technology for devel-oping sophisticated and exquisite architecture through hierarchical printing.It has also been employed in various advanced industrial areas.The development of intelligent biomedical engineering has raised the requirements for 3D printing,such as flexible manufacturing processes and technologies,biocompatible constituents,and alternative bioproducts.However,state-of-the-art 3D printing mainly involves inorganics or polymers and generally focuses on traditional industrial fields,thus severely limiting applications demanding biocompatibility and biodegradability.In this regard,peptide architectonics,which are self-assembled by programmed amino acid sequences that can be flexibly functionalized,have shown promising potential as bioinspired inks for 3D printing.Therefore,the combination of 3D printing and peptide self-assembly poten-tially opens up an alternative avenue of 3D bioprinting for diverse advanced applications.Israel,a small but innovative nation,has significantly contributed to 3D bioprinting in terms of scientific studies,marketization,and peptide architectonics,including modulations and applications,and ranks as a leading area in the 3D bioprinting field.This review summarizes the recent progress in 3D bioprinting in Israel,focusing on scientific studies on printable components,soft devices,and tissue engineering.This paper further delves into the manufacture of industrial products,such as artificial meats and bioinspired supramolecular architectures,and the mechanisms,physicochemical properties,and applications of peptide self-assembly.Undoubtedly,Israel contributes significantly to the field of 3D bioprinting and should thus be appropriately recognized.

外文关键词：

Israel3D bioprintingBiomanufacturingPeptide self-assemblyIntegration of industry,education and research

作者：

Lujing Gao、Zixuan Liu、Daniel Dikovsky、Jiqian Wang、Deqing Mei、Lihi Adler-Abramovich、Ehud Gazit、Kai Tao

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作者单位：

State Key Laboratory of Heavy Oil Processing and Centre for Bioengineering and Biotechnology,College of Chemistry and Chemical Engineering,China University of Petroleum(East China),Qingdao 266580,China

Future Science Research Institute,Hangzhou Global Scientific and Technological Innovation Centre,Hangzhou 311200,China

Zhejiang-Israel Joint Laboratory of Self-Assembling Functional Materials,Hangzhou 311200,China

Redefine Meat Ltd.,Rehovot 7670110,Israel

State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China

Key Laboratory of Advanced Manufacturing Technology of Zhejiang Province,School of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China

Department of Oral Biology,The Maurice and Gabriela Goldschleger School of Dental Medicine,Faculty of Medical&Health Sciences,Tel Aviv University,Tel Aviv 6997801,Israel

The Center for Nanoscience and Nanotechnology,Tel Aviv University,Tel Aviv 6997801,Israel

Department of Materials Science and Engineering,Iby and Aladar Fleischman,Tel Aviv University,Tel Aviv 6997801,Israel

The Shmunis School of Biomedicine and Cancer Research,George S.Wise Faculty of Life Sciences,Tel Aviv University,Tel Aviv 6997801,Israel

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基金：

National Key Research and Development Program of China within the China-Israel Cooperative Scientific Research国家自然科学基金国家自然科学基金Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang Province,ChinaZhejiang University Global Partnership FundOpen Foundation of the State Key Laboratory of Fluid Power and Mechatronic Systems

项目编号：

2022YFE0100800Israeli 3-1813052175551220721812022R01001GZKF-202224

出版年：

2024

DOI：

10.1007/s42242-024-00275-5

生物设计与制造(英文)

ISSN：2096-5524

年,卷(期)：2024.7(3)