首页|A drug-loaded flexible substrate improves the performance of conformal cortical electrodes
A drug-loaded flexible substrate improves the performance of conformal cortical electrodes
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Cortical electrodes are a powerful tool for the stimulation and/or recording of electrical activity in the nervous system.However,the inevitable wound caused by surgical implantation of electrodes presents bacterial infection and inflammatory reaction risks associated with foreign body exposure.Moreover,inflammation of the wound area can dramatically worsen in response to bacterial infection.These consequences can not only lead to the failure of cortical electrode implantation but also threaten the lives of patients.Herein,we prepared a hydrogel made of bacterial cellulose(BC),a flexible substrate for cortical electrodes,and further loaded antibiotic tetracycline(TC)and the anti-inflammatory drug dexamethasone(DEX)onto it.The encapsulated drugs can be released from the BC hydrogel and effectively inhibit the growth of Gram-negative and Gram-positive bacteria.Next,therapeutic cortical electrodes were developed by integrating the drug-loaded BC hydrogel and nine-channel serpentine arrays;these were used to record electrocorticography(ECoG)signals in a rat model.Due to the controlled release of TC and DEX from the BC hydrogel substrate,therapeutic cortical electrodes can alleviate or prevent symptoms associated with the bacterial infection and inflammation of brain tissue.This approach facilitates the development of drug delivery electrodes for resolving complications caused by implantable electrodes.
Frontiers Science Center for Flexible Electronics(FSCFE),Xi'an Institute of Flexible Electronics(IFE)and Xi'an Institute of Biomedical Materials & Engineering(IBME),Northwestern Polytechnical University,Xi'an 710072,China
Unmanned System Research Institute,Northwestern Polytechnical University,Xi'an 710072,China
Ministry of Education Key Laboratory of Micro and Nano Systems for Aerospace,School of Mechanical Engineering,Northwestern Polytechnical University,Xi'an 710072,China
Key Laboratory of Flexible Electronics of Zhejiang Province,Ningbo Institute of Northwestern Polytechnical University,Ningbo 315103,China
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National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaShaanxi Provincial Science Fund for Distinguished Young ScholarsScience and Technology Innovation 2030-Major ProjectShanghai Sailing ProgramChina National Postdoctoral Program for Innovative Talents
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