Deep brain implantable microelectrode arrays for detection and functional localization of the subthalamic nucleus in rats with Parkinson's disease

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外文摘要：The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson's disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise stimulation.In this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocom-posites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths.These results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains.In addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN.Moreover,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN localization.Compared with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains.This may be a cause of sleep and motor disorders associated with PD.Overall,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.

外文关键词：

Functional localizationImplantable microelectrode arraysParkinson's diseaseSubthalamic nucleus

作者：

Luyi Jing、Zhaojie Xu、Penghui Fan、Botao Lu、Fan Mo、Ruilin Hu、Wei Xu、Jin Shan、Qianli Jia、Yuxin Zhu、Yiming Duan、Mixia Wang、Yirong Wu、Xinxia Cai

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作者单位：

State Key Laboratory of Transducer Technology,Aerospace Information Research Institute,Chinese Academy of Sciences,Beijing 100190,China

School of Electronic,Electrical and Communication Engineering,University of Chinese Academy of Sciences,Beijing 100049,China

基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFrontier Interdisciplinary Project of the Chinese Academy of SciencesNational Key Research and Development Program of ChinaNational Key Research and Development Program of ChinaMajor Program of Scientific and Technical Innovation 2030Scientific Instrument Developing Project of the Chinese Academy of Sciences

项目编号：

L2224042T2293731621210036196020601261973292621714346197520661971400XK2022XXC0032022YFC24025012022YFB32056022021ZD02016030GJJSTD20210004

出版年：

2024

DOI：

10.1007/s42242-023-00266-y

生物设计与制造(英文)

ISSN：2096-5524

年,卷(期)：2024.7(4)