Rapid fabrication of modular 3D paper-based microfluidic chips using projection-based 3D printing

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外文摘要：Paper-based microchips have different advantages,such as better biocompatibility,simple production,and easy handling,making them promising candidates for clinical diagnosis and other fields.This study describes a method developed to fabricate modular three-dimensional(3D)paper-based microfluidic chips based on projection-based 3D printing(PBP)technology.A series of two-dimensional(2D)paper-based microfluidic modules was designed and fabricated.After evaluating the effect of exposure time on the accuracy of the flow channel,the resolution of this channel was experimentally analyzed.Furthermore,several 3D paper-based microfluidic chips were assembled based on the 2D ones using different methods,with good channel connectivity.Scaffold-based 2D and hydrogel-based 3D cell culture systems based on 3D paper-based microfluidic chips were verified to be feasible.Furthermore,by combining extrusion 3D bioprinting technology and the proposed 3D paper-based microfluidic chips,multiorgan microfluidic chips were established by directly printing 3D hydrogel structures on 3D paper-based microfluidic chips,confirming that the prepared modular 3D paper-based microfluidic chip is potentially applicable in various biomedical applications.

外文关键词：

Paper-based microfluidic chipProjection-based 3D printing(PBP)ModularizationCell culture

作者：

Mingjun Xie、Zexin Fu、Chunfei Lu、Sufan Wu、Lei Pan、Yong He、Yi Sun、Ji Wang

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作者单位：

Plastic and Reconstructive Surgery Center,Department of Plastic and Reconstructive Surgery,Zhejiang Provincial People's Hospital,Affiliated People's Hospital,Hangzhou Medical College,Hangzhou 310014,China

State Key Laboratory of Fluid Power and Mechatronic Systems,School of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China

Key Laboratory of Materials Processing and Mold,Zhengzhou University,Zhengzhou 450002,China

Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province,College

Key Laboratory of 3D Printing Process and Equipment of Zhejiang Province,College of Mechanical Engineering,Zhejiang University,Hangzhou 310058,China

Cancer Center,Zhejiang University,Hangzhou 310058,China

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基金：

National Natural Science Foundation of ChinaScience Fund for Creative Research Groups of the National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaFellowship of China Postdoctoral Science FoundationNational Natural Science Foundation of ChinaZhejiang Provincial Natural Science Foundation of China

项目编号：

52235007T2121004523053002022M72282682203602LQ22H160020

出版年：

2024

DOI：

10.1007/s42242-024-00298-y

生物设计与制造(英文)

ISSN：2096-5524

年,卷(期)：2024.7(5)