Enhanced wear resistance,antibacterial performance,and biocompatibility using nanotubes containing nano-Ag and bioceramics in vitro

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外文摘要：A good Ti-based joint implant should prevent stress shielding and achieve good bioactivity and anti-infection performance.To meet these requirements,the low-elastic-modulus alloy—Ti-35Nb-2Ta-3Zr—was used as the substrate,and functional coatings that contained bioceramics and Ag ions were prepared for coating on TiO2 nanotubes(diameter:(80±20)nm and(150±40)nm)using anodization,deposition,and spin-coating methods.The effects of the bioceramics(nano-β-tricalcium phosphate,microhydroxyapatite(micro-HA),and meso-CaSiO3)and Ag nanoparticles(size:(50±20)nm)on the antibacterial activity and the tribocorrosion,corrosion,and early in vitro osteogenic behaviors of the nanotubes were investigated.The tribocorrosion and corrosion results showed that the wear rate and corrosive rate were highly dependent on the features of the nanotube surface.Micro-HA showed great wear resistance with a wear rate of(1.26±0.06)x 10-3 mm3/(N·m)due to adhesive and abrasive wear.Meso-CaSiO3 showed enhanced cell adhesion,proliferation,and alkaline phosphatase activity.The coatings that contained nano-Ag exhibited good antibacterial activity with an antibacterial rate of ≥89.5％against Escherichia coli.These findings indicate that hybrid coatings may have the potential to accelerate osteogenesis.

外文关键词：

βTi alloySurface modificationWear resistanceCorrosion resistanceOsteogenic behaviorAntibacterial activity

作者：

Qingge Wang、Jia Liu、Hong Wu、Jingbo Liu、Yaojia Ren、Luxin Liang、Xinxin Yan、Ian Baker、Shifeng Liu、V.V.Uglov、Chengliang Yang、Liqiang Wang

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作者单位：

State Key Laboratory of Powder Metallurgy,Central South University,Changsha,410083,China

Affiliated Hospital of Youjiang Medical University for Nationalities,Guangxi Key Laboratory for Preclinical and Translational Research on Bone and Joint Degenerative Diseases,Guangxi Zhuang Autonomous Region Engineering Research Center for Biomaterials in Bone and Joint Degenerative Diseases,Guangxi Key Laboratory for Biomedical Material Research,Baise 533000,China

Department of Orthopedics,The Second Xiangya Hospital,Central South University,Changsha 410011,China

Department of Orthopedics,Renmin Hospital,Wuhan University,Wuhan 430060,China

Thayer School of Engineering,Dartmouth College,Hanover,NH 03755-8000,USA

School of Metallurgical Engineering,Xi'an University of Architecture and Technology.Xi'an 710055,China

Belarusian State University,220030 Minsk,Belarus

State Key Laboratory of Metal Matrix Composites,School of Material Science and Engineering,Shanghai Jiao Tong University,Shanghai,200240,China

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基金：

National Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province for Distinguished Young ScholarsHunan Provincial Natural Science Foundation of ChinaCentral South University Research Program of Advanced Interdisciplinary StudiesFunding for the Medical Engineering Cross Disciplinary Project at Shanghai Jiao Tong UniversityFundamental Research Funds for the Central Universities of Central South UniversitySinoma Institute of Materials Research(Guangzhou)Co.,Ltd.for the assistance with the TEM characterization

项目编号：

5207134652111530193522743872023JJ100752021JJ308462023QYJC0382022ZZTS0402

出版年：

2024

DOI：

10.1007/s42242-024-00279-1

生物设计与制造(英文)

ISSN：2096-5524

年,卷(期)：2024.7(5)