A drinking model with permanent quitting drinker compartment and relapse is derived.Mathematical analyses show that the model admits a drinking-free equilibrium and a drinking-present equilibrium.It is shown that the drinking-free equilibrium is globally asymptotically stable if R0 < 1,the drinking-present equilibrium is globally asymptotically stable if R0 > 1.Numerical simulations are also provided to illustrate our analytical results.