Research progress of gastrointestinal physiological functions associated to defecation by the circadian rhythm
This paper has reviewed the mechanism of circadian rhythm regulating of intestinal function.By analyzing and summarizing the relevant literature at home and abroad,this review summarizes the regula-tion of intestinal motility,brain-gut peptides secretion,gut microbiota homeostasis and intestinal barrier func-tion by circadian rhythm and discusses the possible mechanism of functional constipation induced by circadian rhythm disruption based on clinical studies.Circadian rhythm regulates intestinal function,which affecting the invasion of constipation.Improving patients'daily life and reconstructing circadian rhythm may become a new strategy for the treatment of FC in the future.