昼夜节律调控排便相关胃肠生理功能的研究进展
Research progress of gastrointestinal physiological functions associated to defecation by the circadian rhythm
丁劭华 1沈洪2
作者信息
- 1. 南京中医药大学 第一临床医学院,江苏 南京 210023
- 2. 南京中医药大学 附属医院,江苏 南京 210029
- 折叠
摘要
对昼夜节律调控排便相关胃肠生理功能的机制进行了综述.通过对国内外相关文献进行分析总结,分别从结肠运动、脑肠肽的分泌、肠道菌群及其代谢产物稳态和肠道屏障4 个方面总结归纳了昼夜节律对排便相关胃肠生理功能的调控机制,并结合临床研究探讨了昼夜节律紊乱诱发功能性便秘(FC)的可能机制.昼夜节律紊乱导致胃肠功能失调可能诱发FC,治疗FC可以将优化患者生活作息、恢复昼夜节律作为导向,为未来用药提供了新思路.
Abstract
This paper has reviewed the mechanism of circadian rhythm regulating of intestinal function.By analyzing and summarizing the relevant literature at home and abroad,this review summarizes the regula-tion of intestinal motility,brain-gut peptides secretion,gut microbiota homeostasis and intestinal barrier func-tion by circadian rhythm and discusses the possible mechanism of functional constipation induced by circadian rhythm disruption based on clinical studies.Circadian rhythm regulates intestinal function,which affecting the invasion of constipation.Improving patients'daily life and reconstructing circadian rhythm may become a new strategy for the treatment of FC in the future.
关键词
昼夜节律/便秘/胃肠/生理功能/研究进展Key words
circadian rhythm/constipation/gastrointestine/physiology function/research progress引用本文复制引用
基金项目
国家中医药管理局全国名老中医药专家传承工作项目(国中医药人教函[2021]270号)
江苏省医学创新中心项目(苏卫科教[2022]15号)
出版年
2024
NETL
NSTL
维普
万方数据