Objective To study triterpenoids from the fruits of Melia toosendan Sieb.Et Zucc..Methods The ethyl acetate extracts of M.toosendan were isolated and purified by silica gel column chromatography and ostade-cylsilane reversed phase column chromato-graphy.The compounds were identified by physicochemical methods and spectral data analyses.Results Five triterpenoids were obtained from the fruits of M.toosendan and identified as(21S,23R,24R)-21,23-epoxy-21,24-dihydroxy-25-methoxytirucall-7-en-3-one(compound 1),Cinamodiol,Meliasenin G,21R,23R-epoxy-21α-ethoxy-24S,25-dihydroxy-apotirucall-7-en-3-one,Toosendine E,respectively.Conclusion All compounds are tirucallane-type triterpenoid derivatives.It is the first time that compound 1 is isolated from the fruits of M.toosendan.
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