Determination of six heavy metal elements in Acacia by ICP-MS after microwave digestion
Objective To establish an microwave digestion-inductively coupled plasma mass spectrometry(ICPMS)method for simul-taneously determining the contents of six heavy metal elements in Acacia.Methods The Acacias were digested with nitric acid by the microwave digestion,and then the contents of Hg,V,Cd,Co,As and Pb were determined by inductively coupled plasma mass spec-trometry(ICP-MS).Results The linear equation was Y=2 500.668 3ρ+370.020 0(n=6,R2=0.999 6)for Hg,Y=4 388.276 3ρ+25.000 0(n=6,R2=0.999 1)forV,Y=1 752.864 5ρ+0.000 1(n=6,R2=0.999 1)for Cd,Y=12 593.112 3ρ+25.000 0(n=6,R2=0.998 9)for Co,Y=717.067 0ρ+15.000 0(n=6,R2=0.998 6)for As,and Y=7 612.563 7ρ+170.010 0(n=6,R2=0.9995)for Pb.The method showed good precision and repeatability in the linearity range of 0-100 ng/mL for these six elements.The detection limits of Hg,V,Cd,Co,As and Pb were 0.000 5 mg/kg,0.000 4 mg/kg,0.000 2 mg/kg,0.000 3 mg/kg,0.001 0 mg/kg,0.000 4 mg/kg,respectively.The quantitation limits of Hg,V,Cd,Co,As,Pb were 0.001 7 mg/kg,0.001 2 mg/kg,0.001 8 mg/kg,0.001 0 mg/kg,0.003 4 mg/kg,0.001 3 mg/kg,respectively.The average recoveries of the six elements were 91.12％-104.60％.Conclusion ICP-MS method is specific,convenient and fast for determination of trace mental elements content in Acacia.
Acaciatrace metal elementsICP-MSpharmaceutical excipientICH Q3D
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