Bidirectional Mendelian randomization study on causal relationship between depression and non-alcoholic fatty liver disease
Objective To investigate the causal relationship between major depression disease(MDD)and non-alcoholic fatty liver disease(NAFLD)by two-sample Mendelian randomization(MR)methods.Methods The summary data of the publicly available Genome-Wide Association Study(GWAS)were analyzed.The GWAS summary data were all from the European population.The inverse variance weighted(IVW)method,MR-Egger regression method and weighted median method were used for bidirectional two-sample MR analysis to evaluate the causal relationship between MDD and NAFLD.Sensitivity analysis was used to evaluate the stability and the reliability of the results.Results The results of positive MR analysis showed a causal relationship between MDD and the risk of NAFLD(IVW:OR=1.307,95%CI 1.051-1.626,P=0.016).Sensitivity analysis results showed no horizontal pleiotropy or heterogenei-ty,and the leave-one-out method results showed that eliminating any single SNP did not affect the overall effect estimate.The re-sults of reverse MR analysis showed no causal relationship between NAFLD and the risk of MDD(P>0.05).Conclusion Mendelian ran-domization results suggest that MDD can increase the risk of NAFLD.
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