Carotid artery CTA assessed the degree of carotid atherosclerosis stenosis and its correlation with serum Lp-PLA2 and ANCPTL8 levels
Objective:To investigate the correlation of carotid artery computed tomography angiography(CTA)to the degree of carotid atherosclerosis stenosis and the levels of serum lipoprotein-associated phospholipase A2(Lp-PLA2)and angiopoietin-like protein 8(ANCPTL8).Methods:A total of 155 patients with carotid atherosclerosis combined with carotid artery stenosis were selected as the combined group,and divided into mild group(n=50),moderate group(n=38)and severe group(n=67)according to the severity of the disease,and 92 patients with sim-ple carotid atherosclerosis were selected as the non-combined group.Serum Lp-PLA2 and ANCPTL8 levels in pa-tients with carotid artery stenosis of different severity were compared,and the risk factors of carotid artery stenosis in patients with carotid atherosclerosis were analyzed by multivariate Logistic regression.Digital subtraction angiogra-phy(DSA)was used as the gold standard to analyze the evaluation value of CTA in detecting the degree of carotid artery stenosis.Results:Compared with DSA,CTA showed no significant difference(P＞0.05).Compared with mild group,the serum levels of Lp-PLA2 and ANCPTL8 in moderate group and severe group were significantly increased(all P＜0.05);compared with moderate group,the serum levels of Lp-PLA2 and ANCPTL8 in severe group were significantly increased(all P＜0.05).There were no significant differences in age,sex,smoking history,hyperlipi-demia,serum high density lipoprotein and low density lipoprotein levels between the two groups(all P＞0.05).The proportion of patients with hypertension,diabetes,coronary heart disease,serum Lp-PLA2 and ANCPTL8 levels in the combined group were significantly higher than those in the non-combined group(all P＜0.05).Hypertension,di-abetes,coronary heart disease,high serum Lp-PLA2 and ANCPTL8 levels were risk factors for carotid artery steno-sis in patients with carotid atherosclerosis(all P＜0.05).Serum Lp-PLA2 and ANCPTL8 levels were highly correla-ted with the degree of carotid artery stenosis,and were negatively correlated with them(all P＜0.05).Conclusion:Carotid CTA has a high value in evaluating the degree of carotid artery stenosis,and serum Lp-PLA2 and ANCPTL8 levels are highly correlated with the degree of carotid artery stenosis.Hypertension,diabetes,coronary heart disease,high serum Lp-PLA2 and ANCPTL8 levels are risk factors for carotid artery stenosis in patients with carotid athero-sclerosis.
万方数据
维普
