Correlation between serum MCP-1,AOPP,UACr and prognosis of patients with chronic renal failure after hemodialysis treatment
Objective:To investigate the relationship between serum monocyte chemotactic protein 1(MCP-1),advanced oxidized protein product(AOPP),urinary microalbumin/creatinine ratio(UACr)and the prognosis of pa-tients with chronic renal failure(CRF)after hemodialysis treatment.Methods:A total of 116 patients with CRF un-dergoing hemodialysis were selected as the study objects,and the prognosis was used as the grouping criterion,that is,the good prognosis group and the poor prognosis group.Serum MCP-1,AOPP and urine UACr levels of the two groups were measured respectively,and the relationship between them and the prognosis of CRF hemodialysis treat-ment was analyzed.Receiver operating characteristic curve(ROC)was used to analyze the prognostic value of the three factors.Results:Among 116 patients treated with CRF hemodialysis,42 cases(36.21％)had poor prognosis and 74 cases(63.79％)had good prognosis.There were significant differences in age,comorbidities,ALB,MCP-1,AOPP and UACr among patients with different prognosis(all P＜0.05).Serum MCP-1,AOPP and UACr levels were positively correlated with poor prognosis of CRF hemodialysis(all P＜0.05).The area under the curve(AUC)of MCP-1,AOPP and UACr for prognosis of hemodialysis treatment was 0.875(95％CI:0.718～3.921),the sensitivity was 87.50％,and the specificity was 90.79％(all P＜0.05).Conclusion:The serum levels of MCP-1,AOPP and UACr are in-creased in patients with poor prognosis after hemodialysis treatment of CRF,which are closely related to the prognosis.
万方数据
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