Objective:To investigate the efficacy of interventional embolization in the treatment of aneurysmal Subarachnoid hemorrhage(aSAH)and its effect on serum HMGB1,sICAM-1 and sVCAM-1.Methods:92 patients with aSAH were selected as the research target.According to the different surgical methods,46 patients were divided into the control group(intracranial aneurysm clipping treatment)and the observation group(vascular intervention embolization treatment).The immune function and serum levels of sICAM-1,sVCAM-1 and HMGB1were compared between the two groups before and after treatment The incidence of complications,length of hospital stay,and evalu-ation of prognosis.Results:Observation group operation time,length of hospital stay(92.03±14.97)min,respective-ly(18.73±4.41)d of operation time is shorter than control group(147.92±34.21)min,postoperative length of hospital stay(23.35±4.15)d(all P＜0.05).Postoperative observation group of immune function is better than the control group(all P＜0.05).Postoperative observation group HMGB1,sICAM-1,sVCAM-1 level is lower than the control group(all P＜0.05).The control rate was 47.82％(22/46)is lower than the observation group good prog-nosis good prognosis rate was 69.59％(32/46)(all P＜0.05).The control group 17.39％of the total incidence of 34.78％higher than in observation group(all P＜0.05).Conclusion:Vascular interventional embolization for the treatment of a SAH has the advantages of short surgical time,low incidence of cerebral vasospasm,minimal impact on immune status,and can significantly reduce serum levels of HMGB1,sICAM-1,and sVCAM-1.
维普
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