Effects of asd-guided interventional thrombophilia on vascular endothelial function and serum levels of TXA2 and CXCL16 in patients with acute cerebral infarction
Effects of asd-guided interventional thrombophilia on vascular endothelial function and serum levels of TXA2 and CXCL16 in patients with acute cerebral infarction
Objective:To determine the effects of lower nerve intervention thrombotomy guided by subtraction digital angiography(DSA)on vascular endothelial function and levels of thrombothrombin A2(TXA2)and chemo-kine-cxc-16 ligande(CXCL16)in patients with acute cerebral infarction.Methods:Sixty-one patients with acute cere-bral infarction were selected and assigned to the control group(n=27)and observation group(n=34)depending on the treatment.The control protocol was venous thrombosis with alteplase(rt-Pa)and the observation group,inter-ventional neurological thrombosis guided by DSA;Comparison of levels of CXCL16,TXA2,neurological function and daily living ability,clinical efficacy,endothelial cell function,blood clotting and vascular recollection between the two groups.Results:The total effective rate of observation group and control group was 91.17％and 70.37％,respective-ly(all P＜0.05).Observation group was treated by plasma CXCL16,TXA2 levels significantly decreased compared with control group(all P＜0.05).The NIHSS and mRS Scores in the observation group were significantly lower than those in the control group(all P＜0.05),while BI scores were increased(P＜0.05).After treatment,the serum ET-1 and TXB2 levels in the observation group were significantly decreased,and the level of NO was increased(all P＜0.05).Compared with the control group,the levels of PV,FIB and PAR in the observation group were signifi-cantly decreased after treatment(all P＜0.05).The recanalization rates of the observation group and the control group were 85.26％and 62.96％,respectively(all P＜0.05).Conclusion:DSA guided lower nerve intervention thrombotomy in patients with acute cerebral infarction can rapidly eliminate thrombosis from the diseased vessel,re-store blood flow perfusion,restore vascular endothelial function and reduce serum levels of TXA2 and CXCL16,which is appropriate for clinical use.
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