数字减影血管造影引导下神经介入取栓术对急性脑梗死患者血管内皮功能及血清血栓素A2、CXC趋化因子配体16水平的影响

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中文摘要：目的:探讨数字减影血管造影(DSA)引导下神经介入取栓术对急性脑梗死患者血管内皮功能及血栓素A2(TXA2)、CXC趋化因子配体16(CXCL16)水平的影响。方法:选择急性脑梗死患者122例，通过治疗计划不同分为观察组(n=68)与对照组(n=54)。对照组方案为阿替普酶(rt-PA)静脉溶栓，观察组为DSA引导下的神经介入取栓术;比较两组患者临床疗效、血清CXCL16、TXA2水平、神经功能和日常生活能力、内皮细胞功能、凝血及血管再通情况。结果:观察组、对照组总有效率分别为91。17％、70。37％(均P＜0。05)。经治疗，观察组血清CXCL16、TXA2水平与对照组比较明显降低(均P＜0。05)。观察组患者美国国立卫生研究院卒中评分量表(NIH-SS)、改良Rankin量表(mRS)评分与对照组比较明显降低(均P＜0。05)，日常生活能力指数(BI)评分有所提高(P＜0。05)。治疗后，观察组血清内皮素-1(ET-1)、TXB2水平明显降低，NO水平升高(均P＜0。05)，与对照组比较，观察组患者PV、FIB、PAR水平明显降低(均P＜0。05)。观察组、对照组血管再通率分别为85。29％、62。96％(均P＜0。05)。结论:急性脑梗死患者应用DSA引导下神经介入取栓术可以快速清除病变血管血栓，恢复血流灌注，血管内皮功能改善，降低血清TXA2、CXCL16水平。

外文标题：Effects of asd-guided interventional thrombophilia on vascular endothelial function and serum levels of TXA2 and CXCL16 in patients with acute cerebral infarction

外文摘要：Objective:To determine the effects of lower nerve intervention thrombotomy guided by subtraction digital angiography(DSA)on vascular endothelial function and levels of thrombothrombin A2(TXA2)and chemo-kine-cxc-16 ligande(CXCL16)in patients with acute cerebral infarction.Methods:Sixty-one patients with acute cere-bral infarction were selected and assigned to the control group(n=27)and observation group(n=34)depending on the treatment.The control protocol was venous thrombosis with alteplase(rt-Pa)and the observation group,inter-ventional neurological thrombosis guided by DSA;Comparison of levels of CXCL16,TXA2,neurological function and daily living ability,clinical efficacy,endothelial cell function,blood clotting and vascular recollection between the two groups.Results:The total effective rate of observation group and control group was 91.17％and 70.37％,respective-ly(all P＜0.05).Observation group was treated by plasma CXCL16,TXA2 levels significantly decreased compared with control group(all P＜0.05).The NIHSS and mRS Scores in the observation group were significantly lower than those in the control group(all P＜0.05),while BI scores were increased(P＜0.05).After treatment,the serum ET-1 and TXB2 levels in the observation group were significantly decreased,and the level of NO was increased(all P＜0.05).Compared with the control group,the levels of PV,FIB and PAR in the observation group were signifi-cantly decreased after treatment(all P＜0.05).The recanalization rates of the observation group and the control group were 85.26％and 62.96％,respectively(all P＜0.05).Conclusion:DSA guided lower nerve intervention thrombotomy in patients with acute cerebral infarction can rapidly eliminate thrombosis from the diseased vessel,re-store blood flow perfusion,restore vascular endothelial function and reduce serum levels of TXA2 and CXCL16,which is appropriate for clinical use.

外文关键词：

Cerebral infarctionDSA guided nerve interventional thrombectomyVascular endothelial functionTXA2CXCL16Neurological function

作者：

刘冰、霍会永、赵聪慧、刘晓霞、刘佳佳、张文超

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作者单位：

邯郸市中心医院神经内科,河北邯郸 056001

关键词：

脑梗死数字减影血管造影引导下神经介入取栓术血管内皮功能血栓素A2 CXC趋化因子配体16 神经功能

出版年：

2025

DOI：