Correlation between serum sST2,CysC,CRP and severity of coronary artery disease and prognostic factors
Objective:To investigate the correlation between serum soluble growth STimulation expressed gene2(sST2),Cystatin C(Cys C)and C-reactive protein(CRP)and the severity of coronary artery disease,and to analyze the in-fluencing factors of prognosis.Methods:A total of 170 patients with coronary artery disease were selected as the observation group,and divided into mild stenosis group(53 cases),moderate stenosis group(62 cases)and severe stenosis group(55 ca-ses)according to the severity of coronary artery disease,and 100 healthy subjects were selected as the control group.The se-rum sST2,CysC and CRP levels in different groups were compared,and Pearson correlation analysis was conducted to ana-lyze the relationship between sST2,CYSC and CRP levels and the severity of coronary artery disease.All patients were fol-lowed up for 6 months,and the prognosis was good(118 cases)and poor(52 cases).Multiple Logistic regression was used to analyze the risk factors affecting the prognosis.Results:The levels of sST2,CysC and CRP in the observation group were higher than those in the control group(all P＜0.05).The levels of sST2,CysC and CRP in patients with severe stenosis were higher than those in mild and moderate stenosis groups,and those in moderate stenosis group were higher than those in mild stenosis group(all P＜0.05).Pearson correlation analysis showed that the severity of coronary artery disease was sig-nificantly positively correlated with serum sST2(r=0.727),CysC(r=0.644)and CRP(r=0.889)(all P＜0.05).Multi-ple Logistic regression analysis showed that history of hypertension,history of diabetes,hyperlipidemia,diseased vessels,stent type used in percutaneous coronary intervention,sST2 and CysC were independent risk factors for prognosis(all P＜0.05).Conclusion:The more severe the degree of coronary artery disease,the higher the levels of serum sST2,CysC and CRP.Besides,history of hypertension,history of diabetes,hyperlipidemia,diseased vessels,type of stent used in percutaneous coronary intervention,sST2 and CysC are all independent risk factors affecting the prognosis of patients,which should be paid clinical attention.
万方数据
维普
