The relationship between serum LDH,CK-MB and the severity and adverse prognosis of viral myocarditis patients
Objective:To explore the relationship between serum lactate dehydrogenase(LDH)and creatine ki-nase isoenzyme(CK-MB)and the severity of disease and poor prognosis in patients with viral myocarditis.Methods:A total of 172 patients with viral myocarditis were selected and divided into a mild group(92 cases)and a severe group(80 cases)according to the severity of the disease.The changes of serum LDH and CK-MB levels were com-pared.The subjects were followed up for 12 months and divided into a good prognosis group(100 cases)and a poor prognosis group(72 cases)according to the prognosis.Cox regression was used to analyze the correlation between serum LDH,CK-MB and poor prognosis in patients with viral myocarditis.Results:Serum LDH and CK-MB in mild group were lower than those in severe group,and the differences were statistically significant(all P＜0.05).The sys-tolic blood pressure and diastolic blood pressure of the good prognosis group were higher than those of the poor prog-nosis group,and the levels of serum cTnⅠ,MYO,LDH,CK-MB and the proportion of arrhythmia patients were lower than those of the poor prognosis group,with statistical significance(all P＜0.05).Cox regression analysis showed that systolic blood pressure,arrhythmia,cTnⅠ,LDH≥ 184.93 U/L,CK-MB≥43.48 U/L were risk factors for ad-verse prognosis in patients with viral myocarditis(all P＜0.05).Conclusion:Serum LDH and CK-MB are related to the severity of disease and poor prognosis of patients with viral myocarditis.The higher the serum LDH and CK-MB,the more serious the disease,and the risk of poor prognosis is also increased.
万方数据
维普
