The predictive value of Survivin,HER-2,GCDFP15 and YAP protein expression in postoperative recurrence and metastasis of breast cancer patients
Objective:To study the predictive value of Survivin,human epidermal growth factor receptor 2(HER-2),giant cystic disease fluid protein 15(GCDFP15)and Yes-associated protein(YAP)expression in postop-erative recurrence and metastasis of breast cancer patients.Methods:The pathological tissues and normal tissues adja-cent to breast carcinoma of breast cancer in 156 patients with breast cancer treated by modified radical mastectomy were collected.The expression of Survivin,HER-2,GCDFP15 and YAP protein in cancer tissues and normal tissues adjacent to breast carcinoma of breast cancer patients were compared.All patients were followed up for 2 years after operation.According to the recurrence and metastasis of patients during the follow-up period,they were divided into the Ⅰ group(51 cases)and the Ⅱ group(105 cases).The general data of the two groups were statistically analyzed.The expression of Survivin,HER-2,GCDFP15 and YAP protein in cancer tissues of the two groups was compared.The influencing factors of recurrence and metastasis of breast cancer patients within 2 years after operation and the predictive value of single and combined detection of Survivin,HER-2,GCDFP15 and YAP protein in cancer tissues for recurrence and metastasis of breast cancer patients within 2 years after operation were analyzed.Results:The posi-tive expression rates of Survivin,HER-2 and GCDFP15 protein in cancer tissues were higher than those in normal tis-sues,and the positive expression rate of YAP protein was lower than that in normal tissues(all P＜0.05).The pro-portion of patients with poor differentiation and clinical stage Ⅲ in the Ⅰ group was higher than that in the Ⅱ group(all P＜0.05).The positive expression rates of Survivin,HER-2 and GCDFP15 protein in cancer tissues of the Ⅰgroup were higher than those in the Ⅱ group,and the positive expression rate of YAP protein was lower than that inⅡ group(all P＜0.05).Poor differentiation,clinical stage Ⅲ and positive expression of Survivin,HER-2 and GCD-FP15 protein were independent risk factors for recurrence and metastasis of breast cancer patients within 2 years af-ter operation(OR=2.092,1.992,2.059,1.815,1.857,all P＜0.05).The positive expression of YAP protein was a protective factor for recurrence and metastasis of breast cancer patients within 2 years after operation(OR=0.489,P＜0.05).The area under the curve(AUC)value of Survivin,HER-2,GCDFP15 and YAP protein combined in pre-dicting recurrence and metastasis of breast cancer patients 2 years after operation was higher than that of the four alone(all P＜0.05).Conclusion:The occurrence of breast cancer was related to the expression of Survivin,HER-2,GCDFP15 and YAP protein,and the occurrence of recurrence and metastasis 2 years after operation was related to the degree of differentiation,clinical stage and the expression of Survivin,HER-2,GCDFP15 and YAP protein.At the same time,the combination of Survivin,HER-2,GCDFP15 and YAP protein could effectively improve the predictive value of recurrence and metastasis 2 years after operation in breast cancer patients.
Breast cancerSurvivinHuman epidermal growth factor receptor 2Gross cystic disease fluid pro-teinYes related proteinRecurrenceTransferPredicted value
万方数据
维普
