Relationship and predictive value of miR-542-3p and VCAM-1 expression characteristics in tumor tissues and postoperative recurrence of brain glioma
Objective:To investigate the relationship between the expression of micrornA-542-3p(miR-542-3p)and vascular cell adhesion molecule-1(VCAM-1)in tumor tissues and the recurrence of brain glioma after surgery and its predictive value.Methods:A total of 91 patients with glioma undergoing surgical treatment were selected for clinical study,among which 43 patients had postoperative recurrence one year after surgery(relapse group)and 48 patients had no recurrent lesions one year after surgery(non-recurrence group).The expression difference of miR-542-3p and VCAM-1 in lesion tissue samples after the first operation was compared between the two groups,and the relationship between miR-542-3p and VCAM-1 protein expression and postoperative recurrence of glioma was ana-lyzed,as well as the value of predicting recurrence.Results:The expression level of miR-542-3p in brain glioma tissues of patients with recurrence group was lower than that of non-recurrence group,and the positive expression rate of VCAM-1 protein in brain glioma tissues of patients with recurrence group was higher than that of non-recurrence group,with statistical significance(all P＜0.05).The proportion of patients with cerebral glioma histopathological grade≥Ⅲ,the proportion of poorly differentiated patients,the proportion of patients with non-total resection,and the rate of tumor infiltration in the recurrence group were higher than those in the non-recurrence group,and the pro-portion of patients with postoperative radiotherapy and chemotherapy in the recurrence group was lower than that in the non-recurrence group,with statistical significance(all P＜0.05).Decreased expression of miR-542-3p,positive expression of VCAM-1 protein and incomplete surgical resection were independent risk factors for postoperative re-currence of glioma(all P＜0.05).The AUC values of miR-542-3p expression and VCAM-1 protein in predicting postoperative glioma recurrence were 0.784(95％CI:0.690～0.877)and 0.725(95％CI:0.621～0.829),respec-tively.Conclusion:The expression of miR-542-3p and VCAM-1 protein in brain glioma tissue is closely related to tumor recurrence after surgery,which has certain reference value for clinical prediction.
万方数据
维普
