Research progress on the mechanism and protective strategies of lung injury caused by single-lung ventilation
Single-lung ventilation(OLV)is a common ventilation technique in clinic,which can effectively iso-late the affected lung and achieve the purpose of ventilating the non-operative lung.At present,OLV is widely used in various large-scale operations,which effectively improves the effectiveness and safety of the operation.However,OLV is easy to cause lung injury in the application process.The common types of lung injury are atelectasis,perfu-sion,oxidative stress,operation and high-volume lung injury.The pathogenesis of various types of lung injury is com-plex.According to the mechanism of lung injury,a series of lung protection strategies can be formulated in clinic,such as in-haling appropriate oxygen concentration,selecting effective ventilation mode,tidal volume,continuous positive airway pres-sure and positive end-expiratory pressure,which can gradually improve oxygenation function and relieve lung.
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