Relationship of Serum miR-375 and miR-155 with Clinical Staging and Prognosis of Primary Liver Cancer
Objective To explore the relationship between serum miR-375,miR-155 and clinical staging and prognosis in patients with primary liver cancer.Methods The data of 86 patients with primary liver cancer were retrospectively analyzed.The expression levels of serum miR-375 and miR-155 among patients with different clinical stages were compared,and the correla-tion was analyzed by Spearman correlation coefficient.The patients were divided into metastasis group and non-metastasis group according to extrahepatic metastasis,and the differences in serum miR-375 and miR-155 were compared between the 2 groups of patients.Receiver operating characteristic(ROC)curve was used to analyze the efficiency of the 2 in the diagnosis of clinical staging.The survival was followed up within 1 year,and Kaplan-Meier method and COX proportional hazard model were used for survival analysis.Results There were statistically significant differences in the expression levels of serum miR-375 and miR-155 among patients with different clinical stages(P＜0.05).The expression level of serum miR-375 was negatively correlated with clinical staging of tumor(P＜0.05)while the expression level of miR-155 was positively correlated with clinical staging(P＜0.05).The expression level of serum miR-375 in metastasis group was lower than that in non-metastasis group while the expres-sion level of miR-155 was higher than that in non-metastasis group(P＜0.05).The AUCs of serum miR-375,miR-155 and their combination in the diagnosis of tumor metastasis were 0.898,0.847 and 0.941.The average survival time of patients with high miR-375 expression was longer than that of patients with low miR-375 expression,while the average survival time of patients with high miR-155 expression was shorter than that of patients with low miR-155 expression(P＜0.05).The expression levels of ser-um miR-375 and miR-155 were independent influencing factors for prognosis of patients(P＜0.05).Conclusion Serum miR-375 and miR-155 are closely related to clinical staging of patients,and are independent influencing factors of prognosis.They can be used as important markers of tumor metastasis in primary liver cancer,and provide reference and guidance for clinical diagnosis and treatment.
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