Effects of Transfusion with Irradiated Red Blood Cells and Ordinary Suspended Red Blood Cells on the Levels of CD4+T Cell Subsets in Patients With Liver Cancer
Objective To analyze the effects of transfusion with irradiated red blood cells and ordinary suspended red blood cells on the levels of CD4+T cell subsets in patients with liver cancer.Methods Retrospective analysis was performed on 100 patients with liver cancer.According to the types of red blood cell transfusion,65 patients treated with irradiated red blood cell transfusion were included in irradiated group,and 35 patients treated with ordinary suspended red blood cell transfusion were enrolled as ordinary group.The levels of peripheral blood CD4+T cell subsets(Th1,Th2,Th17,Treg)and cytokines[interleukin-2(IL-2),interleukin-10(IL-10),interleukin-17(IL-17),interferon(IFN-γ)]before blood transfusion and at 14 days after blood transfusion and incidence rate of infection within 3 months after blood transfusion were compared between the 2 groups.The pa-tients were followed up for 3 years after blood transfusion,and the progression-free survival(PFS)was compared between the 2 groups.Results The levels of Th1,IL-2 and IFN-γ in irradiated group at 14 days after blood transfusion were significantly higher than those in ordinary group while the levels of Th2,Treg,IL-10 and IL-17 were significantly lower than those in ordinary group(P＜0.05),but there was no statistical difference in Th 17 between the 2 groups(P＞0.05).The incidence rate of infection in irra-diated group within 3 months after blood transfusion was lower than that in ordinary group(P＞0.05).At 3 years of follow-up after blood transfusion,there was no statistical significance in PFS between the 2 groups(P＞0.05).Conclusion Transfusion with al-logeneic ordinary suspended red blood cells will inhibit the cellular immune function of patients with liver cancer,while transfu-sion with irradiated red blood cells can alleviate the cellular immunosuppressive response caused by allogeneic blood transfusion,and the latter one has a higher application value during liver cancer surgery.
Irradiated red blood cellsOrdinary suspended red blood cellsLiver cancerCD4+T cell subsets
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