Expression and Clinical Significance of FOXP3,CMTM6,Shoc2 in Breast Cancer
Objective To investigate the expression of forkhead box protein P3(FOXP3),chemokine like factor super-family 6(CMTM6),Shoc2 in breast cancer and their relationship with clinicopathological characteristics and prognosis.Methods 51 female patients with breast cancer were selected as the study subjects.The cancerous tissues and normal tissues adjacent to the cancer were collected,and the positive expressions of FOXP3,CMTM6,Shoc2 were detected by immunohistochemical method.General data such as the age of patients were collected to analyze the relationship between the expression of FOXP3,CMTM6,Shoc2 and the clinicopathological characteristics of breast cancer;Follow up for 3 years to analyze the relationship between the ex-pression of three indicators and patient prognosis.Results The positive expression rates of FOXP3,CMTM6,and Shoc2 in cancer tissues were higher than those in adjacent tissues,with statistical significance(P＜0.05).The expression of FOXP3,CMTM6 and Shoc2 was not related to the age,body mass index(BMI)and tumor size of breast cancer patients(P＞0.05);The expressions of FOXP3,CMTM6,and Shoc2 were correlated with the degree of differentiation,clinical stage,and lymph node metastasis of patients(P＜0.05).The 3-year survival rate of patients with positive expression of FOXP3,CMTM6,and Shoc2 was lower than that of pa-tients with negative expression,and the difference was statistically significant(P＜0.05).Conclusion FOXP3,CMTM6 and Shoc2 are highly expressed in breast cancer tissue,closely related to the degree of differentiation,clinical stage,and lymph node metastasis of patients,and participate in the occurrence and development of disease.The higher the expression level of 3 indica-tors,the worse the prognosis of patients.
Breast cancerFork head box protein P3Chemokinin like factor superfamily 6Shoc2Clinical pathological characteristicsPrognosis
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