Expression of HMGB1,MYCN in Pediatric Neuroblastoma Tissues and Its Significance
Objective To explore the expression and clinical significance of the high-mobility group protein B1(HMGB1)and myeloclastoma virus-related genes(MYCN)in pediatric neuroblastoma(NB)tissues.Methods Clinical data of 75 children with NB were retrospectively analyzed.All pathological samples and adjacent tissue samples were collected and exam-ined,and immunohistochemistry was conducted to detect the expression of HMGB1 and MYCN in pathological samples and adja-cent tissue samples.The expression levels of HMGB1 and MYCN in tumor tissues and adjacent tissues were compared,and the re-lationship between HMGB1 expression,MYCN expression and pathological characteristics were analyzed.Results HMGB1 and MYCN positive expression rates in tumor tissues were higher than adjacent tumor tissues(P＜0.05).Tumor metastasis rate,tumor stage Ⅲ rate,and low differentiation rate of HMGB1 positive group was higher than that of HMGB1 negative group(P＜0.05),and tumor metastasis rate,tumor stage Ⅲ rate,and low differentiation rate of MYCN negative group was higher than that of MYCN negative group(P＜0.05).Conclusion HMGB1 and MYCN are highly expressed in pediatric NB tissues,and the positive ex-pression is closely related to tumor metastasis,tumor stage and differentiation degree,or it can be used as a new target for clinical diagnosis and treatment.
Pediatric neuroblastomaHigh mobility group protein B1Myeloclaoma virus-related genesClinical expres-sion
NETL
NSTL
万方数据
