HMGB1、MYCN在儿童神经母细胞瘤组织中的表达及其意义
Expression of HMGB1,MYCN in Pediatric Neuroblastoma Tissues and Its Significance
侯栋亮 1张飞 1韦源1
作者信息
- 1. 450018 郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院
- 折叠
摘要
目的 探讨高迁移率族蛋白B1(HMGB1)、骨髓细胞瘤病毒相关基因(MYCN)在儿童神经母细胞瘤(NB)组织中的表达及临床意义.方法 回顾性分析75例NB患儿临床资料.术中采集所有患儿病理标本及癌旁组织标本,术后及时送至病理科检验,并开展免疫组织化学法检测HMGB1、MYCN在病理标本及癌旁组织标本中的表达情况.比较HMGB1、MYCN在肿瘤组织及癌旁组织中的表达水平;分析HMGB1表达、MYCN表达与病理特征间的关系.结果 肿瘤组织HMGB1阳性表达率、MYCN阳性表达率均高于癌旁组织,差异有统计学意义(P＜0.05).HMGB1阳性组肿瘤转移率、肿瘤分期Ⅲ期率、低分化率高于HMGB1阴性组,差异有统计学意义(P＜0.05);MYCN阳性组肿瘤转移率、肿瘤分期Ⅲ期率、低分化率高于MYCN阴性组,差异有统计学意义(P＜0.05).结论 HMGB1、MYCN在儿童NB组织中呈高表达,且阳性表达与肿瘤转移、肿瘤分期及分化程度存在密切关系,或可作为临床诊疗新靶点.
Abstract
Objective To explore the expression and clinical significance of the high-mobility group protein B1(HMGB1)and myeloclastoma virus-related genes(MYCN)in pediatric neuroblastoma(NB)tissues.Methods Clinical data of 75 children with NB were retrospectively analyzed.All pathological samples and adjacent tissue samples were collected and exam-ined,and immunohistochemistry was conducted to detect the expression of HMGB1 and MYCN in pathological samples and adja-cent tissue samples.The expression levels of HMGB1 and MYCN in tumor tissues and adjacent tissues were compared,and the re-lationship between HMGB1 expression,MYCN expression and pathological characteristics were analyzed.Results HMGB1 and MYCN positive expression rates in tumor tissues were higher than adjacent tumor tissues(P＜0.05).Tumor metastasis rate,tumor stage Ⅲ rate,and low differentiation rate of HMGB1 positive group was higher than that of HMGB1 negative group(P＜0.05),and tumor metastasis rate,tumor stage Ⅲ rate,and low differentiation rate of MYCN negative group was higher than that of MYCN negative group(P＜0.05).Conclusion HMGB1 and MYCN are highly expressed in pediatric NB tissues,and the positive ex-pression is closely related to tumor metastasis,tumor stage and differentiation degree,or it can be used as a new target for clinical diagnosis and treatment.
关键词
儿童神经母细胞瘤/高迁移率族蛋白B1/骨髓细胞瘤病毒相关基因/临床表达Key words
Pediatric neuroblastoma/High mobility group protein B1/Myeloclaoma virus-related genes/Clinical expres-sion引用本文复制引用
出版年
2024
NETL
NSTL
万方数据