Correlation Between Serum CXCL5,sI CAM-1 and Postoperative Outcome in Patients with Non-muscular Invasive Bladder Cancer
Objective To explore the relationship between serum chemokine ligand 5(CXCL5),soluble intercellular adhesion molecule-1(sICAM-1)and postoperative outcome of non-muscular invasive bladder cancer(NMIBC).Methods The convenience sampling method was used to select 118 NMIBC patients who received surgical treatment.The patients were followed up for 1 year after operation to observe the tumor free survival period of the patients.The clinicopathological characteristics and tumor free survival of patients with different levels of CXCL5 and sICAM-1 were compared.COX regression was used to verify the relationship between serum CXCL5 and sICAM-1 levels and postoperative tumor free survival.Kaplan-Meier survival analysis was used to test the tumor free survival of patients with different levels of CXCL5 and sICAM-1.Results By bivariate Pearson corre-lation coefficient test,there was a positive correlation between serum CXCL5 and sICAM-1 levels in NMIBC patients(γ=0.328,P＜0.001).The proportion of NMP22≥10 U/ml and low differentiation patients in the high expression group of serum CXCL5 and sICAM-1 was higher than that in the low expression group,the difference was statistically significant(P＜0.05).However,there was no statistical significant difference in age,sex,TNM stage,lesion size and number of lesions between serum CXCL5 and sICAM-1 different expression groups(P＞0.05).Among 118 patients with NMIBC,34 patients had relapse after one-year follow-up,with a recurrence rate of 28.81％.The results of univariate and multivariate COX regression analysis showed that serum CX-CL5 and sICAM-1 levels were related to the tumor free survival of NMIBC patients(P＜0.05).The overall tumor free survival time of high expression group of serum CXCL5 and sICAM-1 was lower than that of low expression group,the difference was statis-tically significant(P＜0.05).Conclusion The levels of serum CXCL5 and sICAM-1 are correlated with the prognosis of NMI-BC patients.
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