The Relationship Between MnSOD Gene Val16Ala Polymorphism and the Susceptibility of Prostate Cancer Patients with Bone Metastasis
Objective To investigate the relationship between the polymorphism of MnSOD gene Val16Ala and the sus-ceptibility of prostate cancer patients with bone metastasis.Methods 94 patients with prostate cancer were selected as the study objects.Patients were grouped according to whether or not they had bone metastasis.Patients with prostate cancer with bone metas-tasis were classified as bone metastasis group and patients without bone metastasis were classified as prostate cancer group.Clini-cal data(age,course of disease,TNM stage,body mass index,etc.),genetic balance test of MnSOD gene Val16Ala in the two groups,distribution of MnSOD gene Val16Ala polymorphism,and clinical characteristics of prostate cancer patients with different genotypes of bone metastasis were analyzed.Results There were 40 cases of bone metastasis and 54 cases of prostate cancer.There was no significant difference in age,course of disease,TNM stage and body mass index between the two groups(P＞0.05).There was no significant difference in the actual and theoretical frequency distribution of MnSOD gene Val/Val,Val/Ala and Ala/Ala genotypes between bone metastasis group and prostate cancer group(P＞0.05).The frequencies of MnSOD gene Ala/Ala genotype and Ala allele in bone metastasis group were higher than those in prostate cancer group,and the frequencies of Val/Val genotype and Val allele were lower than those in prostate cancer group(P＜0.05).There was no significant difference between MnSOD gene Val16Ala genotype and PSA,age and Gleason score in prostate cancer patients with bone metastasis(P＞0.05).The proportion of Ala/Ala in patients with TNM stage Ⅲ～Ⅳ was 75.00％(18/24)significantly higher than that in pa-tients with stage Ⅰ～Ⅱ(P＜0.05).Conclusion The polymorphism of MnSOD gene Val16Ala is related to the susceptibility of prostate cancer patients with bone metastasis,and may promote the occurrence of bone metastasis of prostate cancer.
NETL
NSTL
万方数据
